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跨学科学术交流讲座:Engineering hepatic cell fate in 3D

发布时间:2013-05-20
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报告人:杜亚楠 研究员
清华大学医学院生物医学工程系
时间:2013 年 5 月 22 日(周三)下午14:30
地点:中国体育彩票现代物理研究中心102 会议室
(老化学楼东配楼一层,理教路西,老光华楼北侧)
报告摘要:

Hepatocyte-based applications, such as metabolism/hepatotoxicity drug testing for drug discovery and bioartificial-liver assisted devices are challenged by the lack of optimal in vitro culture model for hepatocyte functional maintenance and shortage of sustainable cell source. In this talk, two examples will be introduced to take advantage of 3D engineering configurations to tackle these challenges. In the first part, a novel 3D hepatocyte monolayer culture configuration was developed in a bioactive RGD/Galactose hybrid substrate to improve the gold-standard 2D hepatocyte monolayer culture, which can be readily applied for multi-well plate-based high throughput drug testing. In the second part, directed differentiation of human embryonic stem cells (hESCs) are achieved within a micro-patterned platform to recapitulate the embryonic liver development. Compared with 2D planar differentiation, the 3D micro-engineered platform generated more homogenous and mature hepatocyte-like cells with improved hepatic functions. These two 3D configurations for hepatic maintenance and differentiation represent significant step towards better control of hepatic cell fate for their wider applications in drug discovery and medical treatment for liver failures.

报告人简介:
  杜亚楠,博士,研究员,清华大学博士生导师。2002年本科毕业于清华大学化学工程系化学工程与工艺专业。2007年毕业于新加坡国立大学生物工程系并获该专业博士学位。2007年至2010年于美国麻省理工学院(Harvard-MIT Health Science and Technology)和哈佛大学(Brigham &Women’s Hospital, Harvard Medical School)进行博士后研究。20109月起受聘于清华大学医学院生物医学工程系。主要研究方向涉及生物材料、组织工程,干细胞,和微尺度技术。研究内容主要应用微尺度(微米/纳米)技术结合生物材料和细胞生物学为组织工程、干细胞以及用于药物筛选和病理研究的体外模型提供工程手段和解决方法。近五年来发表SCI论文20余篇,其中以第一作者和通讯作者在PNASAdvanced materialsBiotechnology advancesBiomaterialsAdvanced functional materialsLab on ChipTissue engineeringSmall等杂志发表15篇,图书章节8篇,以及批准和正在审批的国际PCT专利5项,国内专利3项。为‘Biomaterials and Biodevices’‘Medical Imaging and Health Informatics’等杂志编委。并为IEEE-Engineering in Medicine and Biology Society (IEEE-EMBS)委员

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