国家精神心理疾病临床医学研究中心 办公室副主任 研究员 博士生导师

工作地址：北京市海淀区花园北路51号，邮编：100191

邮箱：changsh@bjmu.edu.cn

电话：010-61955528

教育经历

2009.7~2012.7 中科院心理研究所，博士，行为遗传学专业

2004.9~2007.7 中科院计算技术研究所，硕士，计算机软件与理论专业，生物信息学

2000.9~2004.7 中国民航大学，理学学士，信息与计算科学专业

工作经历

2024.3～今 中国体育彩票第六医院，研究员

2018.6~2024.2 中国体育彩票第六医院，副研究员

2017.4~2018.5 中国科学院心理研究所，副研究员

2014.5~2015.5 美国北卡罗莱纳大学教堂山分校，遗传和生物统计系，访问学者

2008.6~2017.3 中国科学院心理研究所，研究实习员，助理研究员

2007.10~2008.1 德国吕贝克大学，生物化学研究中心，访问学者

2007.7~2008.5 中国科学院北京基因组研究所，研究实习员

研究方向和研究成果

研究方向包括：1) 利用基因组学和生物信息学技术发现神经发育障碍的遗传位点并整合多维度数据挖掘遗传位点的功能；2) 精神疾病的遗传交叉研究；3) 基于遗传学及其他多维表型数据的疾病风险评估模型研究。

曾入选中国科学院青年创新促进会会员。主持国家自然基金项目4项，国家重点研发计划课题1项，参与“脑科学与类脑研究”国家重大专项、973、北京市脑计划等多项课题。担任Cellular and Molecular Life Sciences杂志的Associate Editor，“脑科学与类脑研究”国家重大专项、国家自然科学基金、英国Wellcome基金、北京市自然科学基金等评审，受邀担任Biological Psychiatry，Brief Bioinformatics等10多个杂志的审稿专家。迄今在国际主流学术期刊发表了70余篇学术论文，其中38篇为第一/通讯作者，包括Molecular Psychiatry 2篇、Biological Psychiatry 1篇、Nucleic Acids Research 3篇，总引用3000多次。

代表性论文

(# 并列第一, * 通讯，2025.7.8统计，Google Scholar Citation: 3311; h-index: 28，完整论文列表及引用见https://scholar.google.com/citations?hl=en&user=gz5FI78AAAAJ)

1. Tao Pang, Li Yang, Yuxin Liu*, Suhua Chang*. The Trajectory of ADHD Symptoms and Its Dynamic Relationship with Inhibitory Control. Journal of Child Psychology and Psychiatry, 2025 Jan 6. doi: 10.1111/jcpp.14112.

2. Chao Liufu#, Lingxue Luo#, Tao Pang, Haohao Zheng, Li Yang, Lin Lu, Suhua Chang*, Integration of multi-omics summary data reveals the role of N6-methyladenosine in neuropsychiatric disorders. Molecular Psychiatry, 2024 Apr 29.

3. Lingxue Luo, Tao Pang, Haohao Zheng, Chao Liufu, Suhua Chang*. xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data. Journal of Translational Medicine, 2024 Apr 25; 22(1):387.

4. Suhua Chang#, Jia-Jia Liu#, Yilu Zhao, Tao Pang, Xiangyu Zheng, Zhirui Song, Anyi Zhang, Xuping Gao, Lingxue Luo, Yanqing Guo*, Jing Liu*, Li Yang*, Lin Lu*. Whole-genome sequencing identifies novel genes for autism in Chinese trios. SCIENCE CHINA - Life Sciences, 2024, doi.org/10.1007/s11427-023-2564-8

5. T Pang, N Ding, Y Zhao, J Zhao*, L Yang*, S Chang*. Novel genetic loci of inhibitory control in ADHD and healthy children and genetic correlations with ADHD. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2024 Jun 8:132:110988.

6. Tian S, Huangfu L, Ai S, Zheng J, Shi L, Yan W, Zhu X, Wang Q, Deng J*, Bao Y*, Chang S*, Lu L.* Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis. SCIENCE CHINA - Life Sciences. 2023 Apr 28.

7. Haohao Zheng, Jie Sun, Tao Pang, Jiajia Liu, Lin Lu, Suhua Chang*. Identify novel, shared and disorder-specific genetic architecture of major depressive disorder, insomnia and chronic pain. Journal of Psychiatric Research 155 (2022) 511–517

8. Su-Hua Chang#, Yan Sun#, Fan Wang, Xiang-Wen Chang, Ying-Jian Zhang, Tian-Ye Jia, Hong-Qiang Sun, Wei-Hua Yue, Ping Wu, Lin Lu*, Jie Shi*. Genome-wide association meta-analyses identify novel genetic risk loci and polygenic phenotype associations for heroin, methamphetamine, and alcohol dependences. Clinical and Translational Medicine 2022;12:e659.

9. Ximei Zhu#, Wei Yan#, Xiao Lin#, Jianyu Que, Yuetong Huang, Haohao Zheng, Lin Liu, Jiahui Deng, Lin Lu*, Suhua Chang*. The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism. Translational Psychiatry, 2022 12:199.

10. Jie Sun, Wei Yan, Xing-Nan Zhang, Xiao Lin, Hui Li, Yi-Miao Gong, Xi-Mei Zhu, Yong-Bo Zheng, Xiang-Yang Guo, Yun-Dong Ma, Zeng-Yi Liu, Lin Liu, Jia-Hong Gao, Michael V. Vitiello, Su-Hua Chang*, Xiao-Guang Liu*, Lin Lu*. Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance. Translational Psychiatry 2020 Jul 24;10(1):252.

11. Suhua Chang, Li Yang*, Yufeng Wang and Stephen V. Faraone*. Shared Polygenic Risk for ADHD, Executive Dysfunction and Other Psychiatric Disorders. Transl Psychiatry. 2020 Jun 9;10(1):182.

12. Yan Sun#, Suhua Chang#, Zhen Liu, Libo Zhang, Fan Wang, Weihua Yue, Hongqiang Sun, Zhaojun Ni, Xiangwen Chang, Yibin Zhang, Yang Chen, Jiqiang Liu, Lin Lu, Jie Shi*, Identification of novel risk loci with shared effects on alcoholism, heroin and methamphetamine dependence. Mol Psychiatry 2019 Aug 28

13. Yang, L.#, Chang, S.#, Lu, Q., Zhang, Y., Wu, Z., Sun, X. et al. A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry 2018. 23(4): 1014-1020.

14. Zhang, K.,#, Qu, S.#, Chang, S.#, Li, G., Cao, C., Olff, M., et al. (2017) An overview of posttraumatic stress disorder genetic studies by integrating and analyzing genetic data into genetic database PTSDgene. Neuroscience and Biobehavioral Reviews. 83: 647-656.

15. Zhang K#, Fan Z#, Wang Y, Faraone SV, Yang L*, Chang S*. Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. The World Journal of Biological Psychiatry 2017: 1-10.

16. Wang, J., Qu, S., Wang, W., Guo, L., Zhang, K., Chang, S.* and Wang, J.* (2016). A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res 82: 23-29.

17. Chang, S.#, Wang, J.#, Zhang, K., and Wang, J.*, (2015) Pathway-Based Analysis for Genome-Wide Association Study Data of Bipolar Disorder Provides New Insights for Genetic Study, Protein & Cell, 6, 912-5.

18. Chang, S.#, Gao, L.#, Li, Z.#, Zhang, W.#, Du, Y., & Wang, J.* (2013) BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry, doi: 10.1016/j.biopsych.2013.04.016

19. Chang, S., Zhang, W., Gao, L., & Wang, J.* (2012) Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein & Cell, 3(7), 526-534. doi: 10.1007/s13238-012-2931-7

20. Zhang, L.#, Chang, S.#, Li, Z., Zhang, K., Du, Y., Ott, J., et al. (2012) ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 40(Database issue), D1003-1009. doi: 10.1093/nar/gkr992